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Target speech separation refers to extracting the target speaker's speech from mixed signals. Despite the recent advances in deep learning based close-talk speech separation, the applications to real-world are still an open issue. Two main challenges are the complex acoustic environment and the real-time processing requirement. To address these challenges, we propose a temporal-spatial neural filter, which directly estimates the target speech waveform from multi-speaker mixture in reverberant environments, assisted with directional information of the speaker(s). Firstly, against variations brought by complex environment, the key idea is to increase the acoustic representation completeness through the jointly modeling of temporal, spectral and spatial discriminability between the target and interference source. Specifically, temporal, spectral, spatial along with the designed directional features are integrated to create a joint acoustic representation. Secondly, to reduce the latency, we design a fully-convolutional autoencoder framework, which is purely end-to-end and single-pass. All the feature computation is implemented by the network layers and operations to speed up the separation procedure. Evaluation is conducted on simulated reverberant dataset WSJ0-2mix and WSJ0-3mix under speaker-independent scenario. Experimental results demonstrate that the proposed method outperforms state-of-the-art deep learning based multi-channel approaches with fewer parameters and faster processing speed. Furthermore, the proposed temporal-spatial neural filter can handle mixtures with varying and unknown number of speakers and exhibits persistent performance even when existing a direction estimation error. Codes and models will be released soon.