论文标题
对癌症治疗氨基酸的饮食限制
Dietary Restriction of Amino Acids for Cancer Therapy
论文作者
论文摘要
蛋白质，核苷酸和脂肪酸的生物合成对于癌细胞的恶性增殖和存活至关重要。累积研究结果表明，氨基酸限制是癌症干预的潜在策略。同时，饮食策略在癌症患者中很受欢迎。但是，仍然缺乏扎实的理由来阐明什么是最好的策略，为什么以及如何。在这里，综合分析和综合总结蛋白质组织中氨基酸的丰度，信号和功能，代谢，免疫和食物组成，表明，间歇性禁食或间歇性饮食赖氨酸限制与正常含量一样，作为间歇性的订书机食品或几周的正常含量，可能会在数天或几周内进行癌症预测，可能具有癌症预测或癌症的潜力。此外，还讨论了包括饮食免疫调节的癌症恶病质的饮食补充剂。
Biosyntheses of proteins, nucleotides and fatty acids, are essential for the malignant proliferation and survival of cancer cells. Cumulating research findings show that amino acid restrictions are potential strategies for cancer interventions. Meanwhile, dietary strategies are popular among cancer patients. However, there is still lacking solid rationale to clarify what is the best strategy, why and how it is. Here, integrated analyses and comprehensive summaries for the abundances, signalling and functions of amino acids in proteomes, metabolism, immunity and food compositions, suggest that, intermittent fasting or intermittent dietary lysine restriction with normal maize as an intermittent staple food for days or weeks, might have the value and potential for cancer prevention or therapy. Moreover, dietary supplements were also discussed for cancer cachexia including dietary immunomodulatory.
