论文标题
实时光谱光声成像的通量补偿
Fluence compensation for real-time spectroscopic photoacoustic imaging
论文作者
论文摘要
最近，我们使用kHz速率波长 - 触发激光和扫描梁递送方法展示了一种集成的光声（PA）和超声（PAU）系统。它使用狭窄的激光束在所需的成像区域上以高重复速率进行辐射，与传统的PA进近使用宽光束照明相比，以低重复的重复。这种方法的一个重要优点是，可以解决在同一点从光通量处解耦局部光吸收的基本问题。在这里，我们提出了一种通知补偿方法，并证明了其在幻影研究中的表现。我们采用了分析通畅模型，扩展了扩散理论的铅笔束倾斜出现在培养基上的情况，并开发了可靠的方法，以使用从多个辐射位置获得的PA测量值估算培养基光学参数。我们使用众所周知的对比代理进行了全面的仿真测试和幻影研究，以验证通风模型和光谱校正的可靠性。
Recently we demonstrated an integrated photoacoustic (PA) and ultrasound (PAUS) system using a kHz-rate wavelength-tunable laser and a swept-beam delivery approach. It irradiates a medium using a narrow laser beam sweeping at high repetition rate over the desired imaging area, in contrast to the conventional PA approach using broad beam illumination at a low repetition. One significant advantage of this approach is that the fundamental problem of decoupling local light absorption at a point from optical fluence at the same point can be solved. Here, we present a fluence compensation method and demonstrate its performance in phantom studies. We adopted analytic fluence models, extending diffusion theory for the case of a pencil beam obliquely incident on a medium, and developed robust methods to estimate medium optical parameters using PA measurements acquired from multiple irradiation positions. We conducted comprehensive simulation tests and phantom studies using well-known contrast-agents to validate the reliability of the fluence models and spectral corrections.
