论文标题
细胞中的microRNA介导的噪声处理：战斗还是游戏？
microRNA-mediated noise processing in cells: a fight or a game?
论文作者
论文摘要
在过去的几十年中，microRNA（miRNA）在生命和理论科学之间的界面上引起了研究人员的注意，因为它们参与了转录后调节和相关疾病。多亏了始终更复杂的实验技术，miRNA作为“噪声处理单元”的作用得到了进一步阐明，通过理论和实验研究的结合，MiRNA噪声控制的两种主要方法已经出现了。虽然一侧miRNA被认为是缓冲基因表达噪声的，但最近有人提出miRNA也可以增加其靶标细胞对细胞变异性。在这篇微型综述中，我们关注miRNA在噪声处理中的作用以及相关理论建模定义的参数的推断。
In the past decades microRNAs (miRNA) have much attracted the attention of researchers at the interface between life and theoretical sciences for their involvement in post-transcriptional regulation and related diseases. Thanks to the always more sophisticated experimental techniques, the role of miRNAs as "noise processing units" has been further elucidated and two main ways of miRNA noise-control have emerged by combinations of theoretical and experimental studies. While on one side miRNA were thought to buffer gene expression noise, it has recently been suggested that miRNA could also increase the cell-to-cell variability of their targets. In this Mini Review, we focus on the miRNA role in noise processing and on the inference of the parameters defined by the related theoretical modelling.
