学术文献库

As synchronized activity is associated with basic brain functions and pathological states, spike train synchrony has become an important measure to analyze experimental neuronal data. Many different measures of spike train synchrony have been proposed, but there is no gold standard allowing for comparison of results between different experiments. This work aims to provide guidance on which synchrony measure is best suitable to quantify the effect of epileptiform inducing substances (e.g. bicuculline (BIC)) in in vitro neuronal spike train data. Spike train data from recordings are likely to suffer from erroneous spike detection, such as missed spikes (false negative) or noise (false positive). Therefore, different time-scale dependent (cross-correlation, mutual information, spike time tiling coefficient) and time-scale independent (Spike-contrast, phase synchronization, A-SPIKE-synchronization, A-ISI-distance, ARI-SPIKE-distance) synchrony measures were compared in terms of their robustness to erroneous spike trains. As a result of the in silico manipulated data, Spike-contrast was the only measure being robust to false negative as well as false-positive spikes. Analyzing the experimental data set revealed that all measures were able to capture the effect of BIC in a statistically significant way, with Spike-contrast showing the highest statistical significance even at low spike detection thresholds. In summary, we suggest the usage of Spike-contrast to complement established synchrony measures, as it is time scale independent and robust to erroneous spike trains.