论文标题
同步枢轴
Synchronized Pivots
论文作者
论文摘要
基于生物信息学的水文尺度和膜构成滑动窗的热力学曲线，在单克隆抗体的恒定片段FC中表现出准确水平的疏水峰或山谷集。这些集合为选定的短区域提供了路线图，其中一些有向氨基酸突变可以产生加速抗体动力学或提高稳定性。这些特征可能揭示了抗体活性的巨大差异
Thermodynamic profiles, based on bioinformatic hydropathicity scales and membrane-fitted sliding windows, exhibit accurately level sets of hydrophobic peaks or valleys in the constant fragment Fc of monoclonal antibodies. These sets provide a roadmap for selected short regions where a few directed amino acid mutations could produce either accelerated antibody kinetics or increased stability. These profiles may reveal dramatic differences in antibody activity
