论文标题
细胞之间形态调节的接触介导的信号传导可以驱动脊椎动物中身体分割的过渡
Morphogen-regulated contact-mediated signaling between cells can drive the transitions underlying body segmentation in vertebrates
论文作者
论文摘要
我们提出了一种统一的机制，该机制重现了在体生成过程中观察到的动力转变序列，胚胎发育过程中的身体分割过程，这在所有脊椎动物中都是不变的。这是通过结合通过受体配体耦合介导的细胞间相互作用与通过形态学梯度引入的全局空间异质性介导的，已知发生的沿前后轴发生的。我们的模型在细胞前中胚层前（PSM）的基因表达中重现了同步的振荡，因为它通过在其后部添加新细胞而生长，然后在其后部添加新细胞，然后进行流动波和随后的活动，并随后以体积类似模式出现。该框架集成了一个与边界组织的模式形成机制，该机制使用了形态梯度提供的位置信息，并与耦合介导的集体动力学的自组织出现，以解释导致分割的过程。
We propose a unified mechanism that reproduces the sequence of dynamical transitions observed during somitogenesis, the process of body segmentation during embryonic development, that is invariant across all vertebrate species. This is achieved by combining inter-cellular interactions mediated via receptor-ligand coupling with global spatial heterogeneity introduced through a morphogen gradient known to occur along the anteroposterior axis. Our model reproduces synchronized oscillations in the gene expression in cells at the anterior of the presomitic mesoderm (PSM) as it grows by adding new cells at its posterior, followed by traveling waves and subsequent arrest of activity, with the eventual appearance of somite-like patterns. This framework integrates a boundary-organized pattern formation mechanism, which uses positional information provided by a morphogen gradient, with the coupling-mediated self-organized emergence of collective dynamics, to explain the processes that lead to segmentation.
