论文标题
量子相关性克服了光学显微镜的光损伤极限
Quantum correlations overcome the photodamage limits of light microscopy
论文作者
论文摘要
最先进的显微镜使用强烈的激光器，可以严重干扰生物学过程，功能和生存能力。这引入了只有量子光子相关性才能克服的性能的硬性限制。在这里，我们证明了这一绝对量子优势，可以超出传统显微镜的无光损伤能力，实现了信噪比。我们在连贯的拉曼显微镜中实现了这一目标，我们将其用于成像具有量子增强对比度和亚波长分辨率的细胞内的分子键。这允许观察否则无法解决的纳米级生物结构。连贯的拉曼显微镜允许在未标记的标本中高度选择性的生物分子手指打印，但是光损伤是许多应用的主要障碍。通过证明可以克服这种障碍，我们的工作为敏感性和成像速度的刻度提高提供了途径。
State-of-the-art microscopes use intense lasers that can severely disturb biological processes, function and viability. This introduces hard limits on performance that only quantum photon correlations can overcome. Here we demonstrate this absolute quantum advantage, achieving signal-to-noise beyond the photodamage-free capacity of conventional microscopy. We achieve this in a coherent Raman microscope, which we use to image molecular bonds within a cell with both quantum-enhanced contrast and sub-wavelength resolution. This allows the observation of nanoscale biological structures that would otherwise not be resolved. Coherent Raman microscopes allow highly selective biomolecular finger-printing in unlabelled specimens, but photodamage is a major roadblock for many applications. By showing that this roadblock can be overcome, our work provides a path towards order-of-magnitude improvements in both sensitivity and imaging speed.
