论文标题
使用磁性粒子成像的高分辨率小鼠脑灌注成像的头线线圈的设计
Design of a Head Coil for High Resolution Mouse Brain Perfusion Imaging using Magnetic Particle Imaging
论文作者
论文摘要
磁性粒子成像（MPI）是一种针对人类应用的新颖而多功能的成像方式。当向上缩放到人的大小时，系统的敏感性自然会降低，因为线圈敏感性取决于孔直径。因此，必须进一步研究推动灵敏度极限的新方法以应对这种损失。在本文中，开发了用于小鼠的专用表面线圈，从而提高了脑成像应用中的灵敏度。与MRI相似，由于与感兴趣区域的附近，开发的表面线圈提高了敏感性。在这项工作中呈现了发达的表面线圈后，可以对只有896 pg fe的示踪剂样品进行成像，并在野生型小鼠模型中检测到小血管和解剖结构。由于当前的灵敏度措施需要示踪系统，一种新的方法来确定没有此要求的灵敏度度量，并验证了MPI接收器系统之间的比较。
Magnetic Particle Imaging (MPI) is a novel and versatile imaging modality developing towards human application. When up-scaling to human size, the sensitivity of the systems naturally drops as the coil sensitivity depends on the bore diameter. Thus, new methods to push the sensitivity limit further have to be investigated to cope for this loss. In this paper a dedicated surface coil for mice is developed, improving the sensitivity in cerebral imaging applications. Similar to MRI the developed surface coil improves the sensitivity due to the closer vicinity to the region of interest. With the developed surface coil presented in this work, it is possible to image tracer samples containing only 896 pg Fe and detect even small vessels and anatomical structures within a wild type mouse model. As current sensitivity measures require a tracer system a new method for determining a sensitivity measure without this requirement is presented and verified to enable comparison between MPI receiver systems.
