论文标题
不是那么普雷斯托吗？外毛细胞中缓慢的prestin的结果
Not so presto? Outcomes of sluggish prestin in outer hair cells
论文作者
论文摘要
Prestin（Slc26a5）是一种对哺乳动物耳朵敏感性必不可少的蛋白质，以\ emph {presto}的名字命名。假设该膜蛋白支持与哺乳动物听力范围相匹配的外毛细胞（OHC）的快速运动，总体上及以后，取决于该物种。 \ emph {Inter}来自孤立的OHC的数据似乎与此类频率一致。但是，最近的一些报告对此假设产生了怀疑，表明该蛋白质的内在过渡速率要低得多，几内亚猪的固有过渡速率约为3 kHz，而没有涵盖动物的听觉频率范围。最近的\ emph {in Vivo}数据还表明，OHC运动的幅度远低于该位置的最佳频率。本报告研究了这些不满观测是否与使用简单的压电模型与OHC的生理功能兼容。
Prestin (SLC26A5), a protein essential for the sensitivity of the mammalian ear, was so named from \emph{presto}. The assumption was that this membrane protein supports fast movement of outer hair cells (OHCs) that matches the mammalian hearing range, up to 20 kHz in general and beyond, depending on the species. \emph{In vitro} data from isolated OHCs appeared to be consistent with such frequencies. However, some recent reports cast doubts on this assumption, suggesting that the intrinsic transition rates of this protein are much lower, about 3 kHz for guinea pigs, not covering the auditory frequency range of the animal. Recent \emph{in vivo} data also show that the amplitude of OHC motion rolls off well below the best frequency of the location. The present report examines whether or not these resent observations are compatible with the physiological function of OHCs by using simple piezoelectric models.
