论文标题
黑色的SARS-COV-2死亡率和血管紧张素-2受体阻滞剂的温度敏感性
SARS-CoV-2 mortality in blacks and temperature-sensitivity to an angiotensin-2 receptor blocker
论文作者
论文摘要
热带气候引起了皮肤色素沉着和控制体液体积，盐含量和压力的机制的适应。对于许多远方祖先转向温带气候的人来说，这些适应被证明是有害的：出现了自然选择和对高血压的敏感性的降低。现在，冠状病毒的肺部炎症可能会受到先天免疫差异的进一步危害。高血压和冠状病毒具有转化酶2（ACE2）的常见血管紧张素，可降低血压并介导病毒进入。为了与较不详细的研究保持一致，长期病例报告表明，通过进一步依赖温度依赖性降低，通过ACE2和继发性血管紧张素受体介导的临界阻滞剂剂量以上，通过阻断原代血管紧张素受体诱导的血压降低。温度依赖性表明与热带遗产的联系以及阻滞剂对冠状病毒感染进展的影响。阳性治疗结果应是由于原发性血管紧张素受体介导的宿主促炎作用以及促进由ACE2通过其他受体介导的反窃听抗炎作用的促进抗炎作用而产生的。这些作用可能涉及先天免疫系统成分（凝集素补体途径，NAD代谢组）。黑色脆弱性 - 基于生理的可能性而不是基于社会经济差异 - 提供了一个重要的线索，可以指导治疗。
Tropical climates provoke adaptations in skin pigmentation and in mechanisms controlling the volume, salt-content and pressure of body fluids. For many whose distant ancestors moved to temperate climes, these adaptations proved harmful: pigmentation decreased by natural selection and susceptibility to hypertension emerged. Now an added risk is lung inflammation from coronavirus that may be furthered by innate immune differences. Hypertension and coronavirus have in common angiotensin converting enzyme 2 (ACE2), which decreases blood pressure and mediates virus entry. In keeping with less detailed studies, a long-term case-report shows that decreased blood pressure induced by blocking a primary angiotensin receptor is supplemented, above critical blocker dosage, by a further temperature-dependent fall, likely mediated by ACE2 and secondary angiotensin receptors. Temperature-dependence suggests a linkage with tropical heritage and an influence of blockers on the progress of coronavirus infections. Positive therapeutic results should result from negation of host pro-inflammatory effects mediated by the primary angiotensin receptor and concomitant promotion of countervailing anti-inflammatory effects mediated by ACE2 through other receptors. These effects may involve innate immune system components (lectin complement pathway, NAD metabolome). Black vulnerability - more likely based on physiological than on socioeconomic differences - provides an important clue that may guide treatments.
