论文标题
新型捕孔介导的运动 - 微管络合物中的振荡
Novel Catchbond mediated oscillations in motor-microtubule complexes
论文作者
论文摘要
机械振荡的产生无处不在，在各种细胞内过程中。我们表明，运动蛋白的接管行为提供了一种通用机制，可以在运动环骨骼细丝复合物中产生自发振荡。我们获得了相图，以表征这种新型捕获键介导的机制如何产生双重性和持续的极限周期振荡，并导致非常独特的稳定性行为，包括在生物学相关方案中的运动微管复合物中的双重和非线性稳定。迄今为止，人们认为生物捕获键的主要功能作用是在受外部力或流场的影响时改善细菌和细胞的表面粘附。取而代之的是，我们的理论研究表明，这种捕获键介导的物理机制的烙印将对整个细胞内过程的影响产生影响，从有丝分裂纺锤体振荡的振荡到肌肉纤维的活性。
Generation of mechanical oscillation is ubiquitous to wide variety of intracellular processes. We show that catchbonding behaviour of motor proteins provides a generic mechanism of generating spontaneous oscillations in motor-cytoskeletal filament complexes. We obtain the phase diagram to characterize how this novel catch bond mediated mechanism can give rise to bistability and sustained limit cycle oscillations and results in very distinctive stability behaviour, including bistable and non-linearly stabilised in motor-microtubule complexes in biologically relevant regimes. Hitherto, it was thought that the primary functional role of the biological catchbond was to improve surface adhesion of bacteria and cell when subjected to external forces or flow field. Instead our theoretical study shows that the imprint of this catch bond mediated physical mechanism would have ramifications for whole gamut of intracellular processes ranging from oscillations in mitotic spindle oscillations to activity in muscle fibres.
