论文标题
生物物理微环境对巨噬细胞激活和体细胞重编程过程中细胞命运决策的影响
The Biophysical Micro-Environment's Influence on Cell Fate Decisions During Macrophage Activation and Somatic Cell Reprogramming
论文作者
论文摘要
已知细胞以深刻的方式感知并响应其机械微环境。各种证据表明，在几个细胞命运的决定中，包括分化和增殖的粘附蛋白相关的蛋白质体系。此外，最近的工作表明，底物地形可以调节成纤维细胞的表观遗传状态，促进细胞重编程和炎症。但是，负责此类现象的效应子仍然知之甚少。在这里，我们探讨了巨噬细胞激活和体细胞重编程过程中细胞态表观遗传和转录调节的生物材料设计，粘附和细胞内力的影响。
Cells are known to sense and respond to their mechanical microenvironment in profound ways. Various evidence has implicated the adhesome, a body of adhesion associated proteins, in several cell fate decisions, including differentiation and proliferation. Furthermore, recent work has demonstrated that substrate topography can modulate the epigenetic state of fibroblasts, facilitate cell reprogramming, and temper inflammation. However, the effectors responsible for such phenomena remain poorly understood. Here we explore the effect of biomaterial design, adhesion, and intracellular forces of the epigenetic and transcriptional regulation of cell state during macrophage activation and somatic cell reprogramming.
