论文标题
基于动态的布尔网络目标控制方法
A Dynamics-based Approach for the Target Control of Boolean Networks
论文作者
论文摘要
我们研究异步布尔网络的目标控制问题，以识别一组节点，其扰动可以将网络的动态驱动从任何初始状态到所需的稳态（或吸引子）。我们对临时扰动特别感兴趣，这些扰动适用于足够的时间，然后释放以检索原始动力学。临时扰动具有避免无法预料后果的明显优势，这可能是由永久扰动引起的。尽管存在臭名昭著的状态空间爆炸问题，但在这项工作中，我们开发了一种有效的方法来计算布尔网络的给定目标吸引子的临时目标控制。我们将我们的方法应用于许多现实生活中的生物网络，并将其性能与基于稳定基准的控制方法进行比较，以证明其功效和效率。
We study the target control problem of asynchronous Boolean networks, to identify a set of nodes, the perturbation of which can drive the dynamics of the network from any initial state to the desired steady state (or attractor). We are particularly interested in temporary perturbations, which are applied for sufficient time and then released to retrieve the original dynamics. Temporary perturbations have the apparent advantage of averting unforeseen consequences, which might be induced by permanent perturbations. Despite the infamous state-space explosion problem, in this work, we develop an efficient method to compute the temporary target control for a given target attractor of a Boolean network. We apply our method to a number of real-life biological networks and compare its performance with the stable motif-based control method to demonstrate its efficacy and efficiency.
