论文标题
微米尺度的SBRE增强NV-NMR光谱法
Micron-scale SABRE-enhanced NV-NMR Spectroscopy
论文作者
论文摘要
钻石中的光学探测的氮态（NV）量子缺陷可以检测出来自大约10个PICOLITER的微米级样品体积的高光谱分辨率的核磁共振（NMR）信号。但是，NV-NMR的关键挑战是检测以毫米浓度的样品。在这里，我们证明了NV-NMR质子浓度敏感性的改善，通过可逆交换（SABER）通过信号扩增（SABER）通过信号扩增（SABER）来改善热极化，从而使小分子样品浓度的微米尺度NMR低为1毫米的picolumers pocolumes infumers。 SBRE增强的NV-NMR技术可以在复杂的微米尺度系统（例如单细胞）中对低浓度分子及其动力学进行检测和化学分析。
Optically-probed nitrogen-vacancy (NV) quantum defects in diamond can detect nuclear magnetic resonance (NMR) signals with high-spectral resolution from micron-scale sample volumes of about 10 picoliters. However, a key challenge for NV-NMR is detecting samples at millimolar concentrations. Here, we demonstrate an improvement in NV-NMR proton concentration sensitivity of about $10^5$ over thermal polarization by hyperpolarizing sample proton spins through signal amplification by reversible exchange (SABRE), enabling micron-scale NMR of small molecule sample concentrations as low as 1 millimolar in picoliter volumes. The SABRE-enhanced NV-NMR technique may enable detection and chemical analysis of low concentration molecules and their dynamics in complex micron-scale systems such as single-cells.
