论文标题

剪切流下的红细胞 - 肉毒少细胞聚集动力学

Erythrocyte-erythrocyte aggregation dynamics under shear flow

论文作者

Abbasi, Mehdi, Farutin, Alexander, Ez-Zahraouy, Hamid, Benyoussef, Abdelilah, Misbah, Chaouqi

论文摘要

红细胞(RBC) - 红细胞 - 悬浮在等离子体中的红细胞倾向于聚集并形成Rouleaux。在聚集期间,第一阶段在于形成RBC双峰[血细胞,分子和疾病25,339(1999)]。尽管聚集体通常由中等流动应力解离,但在某些病理条件下,聚集变得不可逆,从而导致高血粘度和血管闭塞。我们在此处执行二维模拟,以研究在不同条件下剪切流下的双重动态及其对流变学的影响。我们将结果总结在参数空间中的丰富相图中的双重动力学(流量强度,粘附能)中,显示了四种不同类型的Doublet配置和动力学。我们发现,与RBC的实验一致,膜储气罐径向在双重分裂中起着重要作用。这里发现的一个显着特征是,当单个细胞进行翻滚(通过增加囊泡内粘度)时,由于粘附(甚至非常弱)而形成的双重粘液(即使在非常强的剪切速率下)也保持稳定。在这种制度中可以看出,剪切速率的增加会诱导双重构象的适应,从而使骨料能够抵抗细胞细胞脱离。我们表明,双重悬浮液的归一效粘度随着粘附能显着增加,这一事实应影响微循环中的血液灌注。

Red blood cells (RBCs) -- erythrocytes -- suspended in plasma tend to aggregate and form rouleaux. During aggregation the first stage consists in the formation of RBC doublets [Blood cells, molecules, and diseases 25, 339 (1999)]. While aggregates are normally dissociated by moderate flow stresses, under some pathological conditions the aggregation becomes irreversible, which leads to high blood viscosity and vessel occlusion. We perform here two-dimensional simulations to study the doublet dynamics under shear flow in different conditions and its impact on rheology. We sum up our results on the dynamics of doublet in a rich phase diagram in the parameter space (flow strength, adhesion energy) showing four different types of doublet configurations and dynamics. We find that membrane tank-treading plays an important role in doublet disaggregation, in agreement with experiments on RBCs. A remarkable feature found here is that when a single cell performs tumbling (by increasing vesicle internal viscosity) the doublet formed due to adhesion (even very weak) remains stable even under a very strong shear rate. It is seen in this regime that an increase of shear rate induces an adaptation of the doublet conformation allowing the aggregate to resist cell-cell detachment. We show that the normalized effective viscosity of doublet suspension increases significantly with the adhesion energy, a fact which should affect blood perfusion in microcirculation.

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