论文标题

功能连接组指纹:识别个人并通过深度学习预测认知功能

Functional connectome fingerprinting: Identifying individuals and predicting cognitive function via deep learning

论文作者

Cai, Biao, Zhang, Gemeng, Zhang, Aiying, Xiao, Li, Hu, Wenxing, Stephen, Julia M., Wilson, Tony W., Calhoun, Vince D., Wang, Yu-Ping

论文摘要

功能网络连接的动态特征已得到广泛认可和研究。共享和唯一信息都显示在连接组中。但是,对于这种常见模式是否可以预测大脑的个体变异性,即“大脑指纹”,该模式几乎不知道,该模式试图可靠地从受试者群中识别特定的个体。在本文中,我们建议根据自动编码器网络增强单个唯一性。更具体地说,我们依赖于以下假设:跨个体共享的常见神经活动可能会减少个体歧视。通过减少共享活动的贡献,可以提高受试者间的可变性。结果表明,使用稀疏词典学习的自动编码器使用自动编码器进行了完善的连接组,可以成功地将一个人与其余参与者区分开,其精度相当高(剩下的剩下的对,最高为99:5%)。此外,使用完善的功能连接配置文件,也可以更好地预测高级认知行为(例如流体智能,执行功能和语言理解)。正如预期的那样,高阶关联皮层对个人歧视和行为预测有了更多的贡献。拟议的方法提供了一种有希望的方法来增强和利用大脑网络的个性化特征。

The dynamic characteristics of functional network connectivity have been widely acknowledged and studied. Both shared and unique information has been shown to be present in the connectomes. However, very little has been known about whether and how this common pattern can predict the individual variability of the brain, i.e. "brain fingerprinting", which attempts to reliably identify a particular individual from a pool of subjects. In this paper, we propose to enhance the individual uniqueness based on an autoencoder network. More specifically, we rely on the hypothesis that the common neural activities shared across individuals may lessen individual discrimination. By reducing contributions from shared activities, inter-subject variability can be enhanced. Results show that that refined connectomes utilizing an autoencoder with sparse dictionary learning can successfully distinguish one individual from the remaining participants with reasonably high accuracy (up to 99:5% for the rest-rest pair). Furthermore, high-level cognitive behavior (e.g., fluid intelligence, executive function, and language comprehension) can also be better predicted using refined functional connectivity profiles. As expected, the high-order association cortices contributed more to both individual discrimination and behavior prediction. The proposed approach provides a promising way to enhance and leverage the individualized characteristics of brain networks.

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