论文标题
细胞外基质如何影响嵌入式球体的刚性？
How does the extracellular matrix affect the rigidity of an embedded spheroid?
论文作者
论文摘要
细胞组织和聚合物网络都可以从软盘转变为刚性，这是其控制参数的函数，但是，这两个系统经常机械相互作用，这可能会影响其各自的刚性。为了研究这种相互作用，我们考虑了一个顶点模型，其界面张力（一个球体）嵌入了两个维度的春季网络中。我们确定了两个具有不同全球球体形状的政权，该制度受网络中界面张力和张力之间的竞争所产生的压力。在第一个方案中，组织保持紧凑，而在第二个状态下，空化的不稳定性导致组织网络界面处间隙的出现。有趣的是，组织的压缩会促进流体化，而张力则促进了细胞的比对和僵化，而驱动刚化的机制在不稳定性的两侧都不同。
Cellularized tissue and polymer networks can both transition from floppy to rigid as a function of their control parameters, and, yet, the two systems often mechanically interact, which may affect their respective rigidities. To study this interaction, we consider a vertex model with interfacial tension (a spheroid) embedded in a spring network in two dimensions. We identify two regimes with different global spheroid shapes, governed by the pressure resulting from competition between interfacial tension and tension in the network. In the first regime, the tissue remains compact, while in the second, a cavitation-like instability leads to the emergence of gaps at the tissue-network interface. Intriguingly, compression of the tissue promotes fluidization, while tension promotes cellular alignment and rigidification, with the mechanisms driving rigidification differing on either side of the instability.
