论文标题

扩散MRI中编码的张量值编码的梯度波形设计

Gradient waveform design for tensor-valued encoding in diffusion MRI

论文作者

Szczepankiewicz, Filip, Westin, Carl-Fredrik, Nilsson, Markus

论文摘要

每个信号采集沿多个空间方向编码的扩散可以用B量描述。张量值扩散编码的好处是,它将“ B量的形状”解锁为新的编码尺寸。通过调节B量的形状,我们可以控制对微观扩散各向异性的敏感性,该敏感性可以用作对比机制。常规扩散编码无法访问的功能。由于基于张量值扩散编码的成像方法正在发现越来越多的应用程序,因此我们提示了为任何给定应用设计最佳梯度波形的挑战。在这篇综述中,我们首先建立基本的设计目标,以创建用于张量值扩散MRI的场梯度波形。我们还调查了与硬件和生理学施加的限制有关的其他设计注意事项,B量无法捕获的潜在混杂效应以及与编码波形扩散有关的伪影。在整个过程中,我们讨论了预期的妥协和权衡,目的是建立对梯度波形设计及其对准确测量和数据解释的影响。

Diffusion encoding along multiple spatial directions per signal acquisition can be described in terms of a b-tensor. The benefit of tensor-valued diffusion encoding is that it unlocks the "shape of the b-tensor" as a new encoding dimension. By modulating the b-tensor shape, we can control the sensitivity to microscopic diffusion anisotropy which can be used as a contrast mechanism; a feature that is inaccessible by conventional diffusion encoding. Since imaging methods based on tensor-valued diffusion encoding are finding an increasing number of applications we are prompted to highlight the challenge of designing the optimal gradient waveforms for any given application. In this review, we first establish the basic design objectives in creating field gradient waveforms for tensor-valued diffusion MRI. We also survey additional design considerations related to limitations imposed by hardware and physiology, potential confounding effects that cannot be captured by the b-tensor, and artifacts related to the diffusion encoding waveform. Throughout, we discuss the expected compromises and tradeoffs with an aim to establish a more complete understanding of gradient waveform design and its impact on accurate measurements and interpretations of data.

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