论文标题

增长网络的概率方法

A Probabilistic Approach to Growth Networks

论文作者

Jelenkovic, Predrag, Kondev, Jane, Mohapatra, Lishibanya, Momcilovic, Petar

论文摘要

广泛使用的封闭产品形式网络最近作为亚细胞结构的随机生长的主要模型,例如细胞细丝。在基线模型中,均匀的单体从常见的单体池上随机固定并分离到单个细丝上,从而导致看似显式的产品形式溶液。但是,由于此类网络的大规模性质,计算这些解决方案的分区函数在数值上是不可行的。为此,我们基于产品形式溶液和大趋化浓度不平等的概率表示,开发了一种新颖的方法,该方法对细丝长度的边际分布产生了明确的表达。派生分布的参数可以从涉及大差速函数的方程式计算,通常接收封闭形式的代数表达式。从方法论的角度来看,我们方法的基本特征是,即使我们的分析涉及大问题率函数,它也可以为订单一个概率提供确切的结果,这仅特征在对数尺度上消失的概率。

Widely used closed product-form networks have emerged recently as a primary model of stochastic growth of sub-cellular structures, e.g., cellular filaments. In the baseline model, homogeneous monomers attach and detach stochastically to individual filaments from a common pool of monomers, resulting in seemingly explicit product-form solutions. However, due to the large-scale nature of such networks, computing the partition functions for these solutions is numerically infeasible. To this end, we develop a novel methodology, based on a probabilistic representation of product-form solutions and large-deviations concentration inequalities, that yields explicit expressions for the marginal distributions of filament lengths. The parameters of the derived distributions can be computed from equations involving large-deviations rate functions, often admitting closed-form algebraic expressions. From a methodological perspective, a fundamental feature of our approach is that it provides exact results for order-one probabilities, even though our analysis involves large-deviations rate functions, which characterize only vanishing probabilities on a logarithmic scale.

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