论文标题
具有挑战性的真核生物：真核生物祖先的故事
Challenging Eukaryogenesis: The Story of the Eukaryotic Ancestor
论文作者
论文摘要
随着真核生物的起源问题越来越接近答案，古细菌祖先与真核生物与环境，分子，细菌，其他影响和共生体之间的相互作用变得越来越相关。各种研究都指向Lokiarchaeota是相对于真核病的密切古细菌。 Imachi等人于2020年初发表的一项研究能够破译Loki的蛋白质组和基因组，并报告了由于其发现而导致的真核生物发生的全新模型，从而将真核生物的研究转移到了重点关注内吞作用的模型，并将其快速地摄取了Alphaproteobacteria the Alphaproteobacteria the MiTria的模型。 Imachi及其同事提出，由于其形状，Loki的祖先与其他原核生物共生，并促进了共生体之间的分子转移以及允许这种转移所需的膜操作，然后才能随着时间的推移获得原始细节。本文将阐明内共生症的历史以及古细菌和字母菌群之间的盛行内吞作用理论，并在Imachi等人发表之前巩固已知和未知数。将讨论他们的新研究的发现，并且对这些新发现的已知和未知数得到了重新固定。比较了真核生成的两个模型，并在与Imachi及其同事模型前进时，讨论了可能进一步验证这种方法的研究领域，并潜在地使用其他领域的研究工具来回答真核生物如何成为真核生物的持续未知数。
As the question of the origins of eukaryotes comes closer to an answer, the interactions between the archaeal ancestor to eukaryotes and environmental, molecular, bacterial, other influences and symbionts have become increasingly relevant. Various studies have pointed towards the Lokiarchaeota as a close archaeal relative to the eukarya. A study by Imachi et al., published in early 2020, was able to decipher the proteome and genome of the Loki and reported an entirely new model for eukaryogenesis due to its findings, thus shifting research of eukaryogenesis away from models focusing on endocytosis and the rapid acquisition of the alphaproteobacteria that would become the mitochondria. Imachi and colleagues proposed that ancestors of the Loki lived symbiotically with other prokaryotes due to its shape, and facilitated molecular transfer between the symbionts as well as the membrane manipulation necessary to allow such transfer, before acquiring a proto-mitochondria over time. This paper will lay out the history of endosymbiosis and the prevailing theory of endocytosis between archaea and alphaproteobacteria, and consolidates the knowns and unknowns up to before the publication of Imachi et al. The findings of their novel study will be discussed, and the knowns and unknowns with respect to these new findings are re-consolidated. The two models of eukaryogenesis are compared and, in moving forward with Imachi and colleagues model, probable areas of research to further validate this approach are discussed, as well as potential usage of research tools of other fields to answer the persistent unknowns of how eukaryotes came to be.
