论文标题
由密度和曲率驱动的膜上细长和弯曲蛋白的排序理论
A theory of ordering of elongated and curved proteins on membranes driven by density and curvature
论文作者
论文摘要
细胞膜与控制膜形态的无数曲率活性蛋白相互作用，并负责机械敏化和机械转移。其中一些蛋白质（例如包含条形域的蛋白质）是弯曲和拉长的，因此可能采用不同的定向顺序状态，从各向同性型到最大化熵，因为拥挤或适应了基础膜的曲率。在这里，扩展了[Nascimento等。 al，物理。 Rev. E，2017，96，022704]，我们开发了一种平均场密度功能理论，以预测弯曲膜上细长和弯曲的物体的合奏的定向秩序和评估。该理论取决于粒子的显微镜特性，并解释了密度依赖性的各向同性到纽马的转变如何通过各向异性曲率修饰。我们还检查了各向同性和列型阶段的共存。该理论奠定了理解膜蛋白重塑膜与分子顺序之间的相互作用的基础，并在[le roux等。 Al，提交，2020年]。
Cell membranes interact with a myriad of curvature-active proteins that control membrane morphology and are responsible for mechanosensation and mechanotransduction. Some of these proteins, such as those containing BAR domains, are curved and elongated, and hence may adopt different states of orientational order, from isotropic to maximize entropy to nematic as a result of crowding or to adapt to the curvature of the underlying membrane. Here, extending the work of [Nascimento et. al, Phys. Rev. E, 2017, 96, 022704], we develop a mean-field density functional theory to predict the orientational order and evaluate the free-energy of ensembles of elongated and curved objects on curved membranes. This theory depends on the microscopic properties of the particles and explains how a density-dependent isotropic-to-nematic transition is modified by anisotropic curvature. We also examine the coexistence of isotropic and nematic phases. This theory lays the ground to understand the interplay between membrane reshaping by BAR proteins and molecular order, examined in [Le Roux et. al, Submitted, 2020].
