论文标题

病毒蔓延与接触跟踪:两个竞争的传染过程

Virus spread versus contact tracing: two competing contagion processes

论文作者

Reyna-Lara, Adriana, Soriano-Paños, David, Gómez, Sergio, Granell, Clara, Matamalas, Joan T., Steinegger, Benjamin, Arenas, Alex, Gómez-Gardeñes, Jesús

论文摘要

在2020年上半年,许多国家遭受了阻止Covid-19的发病率曲线的增长之后,他们面临着恢复社会和经济活动的挑战。 SARS-COV-2的迅速空气传播性以及缺乏疫苗,要求采取主动遏制措施以避免传播链的传播。最新的最新策略(通常称为测试轨道治疗(TTT))包括测试人群进行诊断,跟踪感染者的接触,并通过隔离所有这些情况进行治疗。更好地描述以前机制的组合作用的动力学过程是传染过程与病原体的传播竞争,从而切断了潜在的传染途径。在这里,我们提出了一个隔室模型,该模型将感染的动力学与接触式追踪和病例隔离结合在一起。我们为有效的病例复制号$ r_c(t)$开发了一个分析表达式,该表达式揭示了接触跟踪在缓解和抑制流行病中的作用。我们表明,感染传播与病例隔离之间存在权衡。如果隔离仅限于有症状的个体,则可以将发病曲线扁平但不弯曲。但是,如果将接触示意图也应用于无症状的个体,则该策略可以弯曲曲线并抑制流行病。定量结果取决于网络拓扑。我们量化了接触追踪的有效性的最重要指标,即它扭转了流行曲线的增加趋势,导致其弯曲的能力。

After the blockade that many nations suffered to stop the growth of the incidence curve of COVID-19 during the first half of 2020, they face the challenge of resuming their social and economic activity. The rapid airborne transmissibility of SARS-CoV-2, and the absence of a vaccine, calls for active containment measures to avoid the propagation of transmission chains. The best strategy up to date, popularly known as Test-Track-Treat (TTT), consist in testing the population for diagnosis, track the contacts of those infected, and treat by quarantine all these cases. The dynamical process that better describes the combined action of the former mechanisms is that of a contagion process that competes with the spread of the pathogen, cutting off potential contagion pathways. Here we propose a compartmental model that couples the dynamics of the infection with the contact tracing and isolation of cases. We develop an analytical expression for the effective case reproduction number $R_c(t)$ that reveals the role of contact tracing in the mitigation and suppression of the epidemics. We show that there is a trade off between the infection propagation and the isolation of cases. If the isolation is limited to symptomatic individuals only, the incidence curve can be flattened but not bended. However, if contact tracing is applied to asymptomatic individuals too, the strategy can bend the curve and suppress the epidemics. Quantitative results are dependent on the network topology. We quantify, the most important indicator of the effectiveness of contact tracing, namely its capacity to reverse the increasing tendency of the epidemic curve, causing its bending.

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