论文标题
正相关的样品节省了汇总的测试成本
Positively Correlated Samples Save Pooled Testing Costs
论文作者
论文摘要
最近,对于COVID-19的大规模测试,对单个测试方法的大幅降低成本降低的小组测试方法引起了很多兴趣。许多研究只是假设一组混合的样品是独立的。但是,对于诸如Covid-19的传染病,这种假设可能是不合理的。具体而言,家庭中的人们倾向于相互感染,因此很可能会呈正相关。通过利用正相关,我们做出以下两个主要贡献。一种是提供严格的证据,即当组中的样本正相关时,可以通过使用Dorfman两阶段方法来实现进一步的成本降低。另一个是提出一种用于使用社交图的汇总测试的分层集聚算法,在社交图中,社交图中的优势连接了两个人之间的频繁社交接触。与Dorfman两阶段算法相比,这种算法可显着降低成本降低(约为20%-35%)。
The group testing approach that achieves significant cost reduction over the individual testing approach has received a lot of interest lately for massive testing of COVID-19. Many studies simply assume samples mixed in a group are independent. However, this assumption may not be reasonable for a contagious disease like COVID-19. Specifically, people within a family tend to infect each other and thus are likely to be positively correlated. By exploiting positive correlation, we make the following two main contributions. One is to provide a rigorous proof that further cost reduction can be achieved by using the Dorfman two-stage method when samples within a group are positively correlated. The other is to propose a hierarchical agglomerative algorithm for pooled testing with a social graph, where an edge in the social graph connects frequent social contacts between two persons. Such an algorithm leads to notable cost reduction (roughly 20%-35%) compared to random pooling when the Dorfman two-stage algorithm is applied.