论文标题
体内稳态生物网络中鲁棒性与可塑性之间的线性相互关系
A Linear Reciprocal Relationship Between Robustness and Plasticity in Homeostatic Biological Networks
论文作者
论文摘要
在生活系统的物理学中，寻找从许多显微镜元素中出现的一些宏观变量的关系是一个核心问题。我们进化了基因调节网络，以使靶基因（部分系统）的表达对环境变化不敏感。然后，我们发现其余基因的表达水平自动增加，作为塑性反应。观察到靶基因和残留基因的平均变化之间观察到负比例，这反映了稳态基因的宏观鲁棒性与调节基因的可塑性之间的互惠。这种互惠遵循杠杆原理，该原理在整个进化过程中都得到了满足，从而施加了进化约束。
In physics of living systems, a search for relationships of a few macroscopic variables that emerge from many microscopic elements is a central issue. We evolved gene regulatory networks so that the expression of target genes (partial system) is insensitive to environmental changes. Then, we found the expression levels of the remaining genes autonomously increase as a plastic response. Negative proportionality was observed between the average changes in target and remnant genes, reflecting reciprocity between the macroscopic robustness of homeostatic genes and plasticity of regulator genes. This reciprocity follows the lever principle, which was satisfied throughout the evolutionary course, imposing an evolutionary constraint.
