论文标题

口服葡萄糖耐受性测试(OGTT)期间葡萄糖动力学的贝叶斯分析

Bayesian Analysis of Glucose Dynamics during the Oral Glucose Tolerance Test (OGTT)

论文作者

Flores-Arguedas, Hugo, Capistrán, Marcos A.

论文摘要

在本文中,我们提出了口服葡萄糖耐受性测试(OGTT)期间血糖水平动力学的模型。这种动态包括胰岛素和胰高血糖素在葡萄糖稳态过程中的作用,作为口服刺激的反应。我们提出了一种与胰岛素分泌,胰高血糖素分泌,胃肠道排空和基础葡萄糖水平有关的五个参数的推断。两个与血液中的葡萄糖水平和胃肠道有关的胰岛素指标,使我们可以为胰岛素敏感性受损的患者提出分类。

In this paper, we propose a model of the dynamics of the blood glucose level during an Oral Glucose Tolerance Test (OGTT). This dynamic includes the action of insulin and glucagon in the glucose homeostasis process as the reaction of an oral stimulus. We propose a Bayesian approach in the inference of five parameters related to insulin secretion, glucagon secretion, gastrointestinal emptying, and basal glucose level. Two insulin indicators related to the glucose level in blood and in the gastrointestinal tract allow us to suggest a classification for patients with impaired insulin sensitivity.

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