论文标题
密码子使用和细菌中蛋白质蛋白相互作用之间的共同进化
Co-evolution between Codon Usage and Protein-Protein Interaction in Bacteria
论文作者
论文摘要
我们研究了遗传序列的密码子使用偏置与细菌种类中蛋白质 - 蛋白质相互作用（PPI）的网络特征之间的相关性。我们在密码子偏置索引空间中使用PCA技术，以表明具有相似模式使用密码子使用模式的基因具有更高的概率，即它们的编码蛋白在功能上连接并相互作用。重要的是，当同时考虑密码子偏置的多个方面时，就会出现此信号。本研究扩展了我们先前对大肠杆菌的观察结果，对34种细菌。这些发现可以使以后对密码子偏见对PPI网络拓扑的可能影响进行研究，目的是改善现有的生物信息学方法来预测蛋白质相互作用。
We study the correlation between the codon usage bias of genetic sequences and the network features of protein-protein interaction (PPI) in bacterial species. We use PCA techniques in the space of codon bias indices to show that genes with similar patterns of codon usage have a significantly higher probability that their encoded proteins are functionally connected and interacting. Importantly, this signal emerges when multiple aspects of codon bias are taken into account at the same time. The present study extends our previous observations on E.Coli over a wide set of 34 bacteria. These findings could allow for future investigations on the possible effects of codon bias on the topology of the PPI network, with the aim of improving existing bioinformatics methods for predicting protein interactions.
