论文标题
牙周韧带再生的组织工程:生物力学规格
Tissue Engineering for Periodontal Ligament Regeneration: Biomechanical Specifications
论文作者
论文摘要
牙周生物力学环境很难研究。通过牙周韧带的复杂几何形状和组成,其机械行为非常取决于载荷的类型(压缩与拉伸载荷;静态与环状载荷;单轴与多轴)和根部(宫颈,中间或副本)周围的位置。牙周韧带的这些不同方面使得难以开发功能性生物材料来治疗牙周疾病引起的牙周附着。这篇综述旨在描述牙周韧带的结构和生物力学特性。特别重要的是结构和生物力学之间存在的紧密相互关系:牙周韧带结构组织特定于其生物力学环境,其生物力学特性特定于其结构排列。结构和生物力学之间的这种平衡可以通过机械敏感的牙周细胞活性来解释。这些规格必须在进一步的组织工程策略中考虑,以开发有效的牙周组织再生生物材料。
The periodontal biomechanical environment is very difficult to investigate. By the complex geometry and composition of the periodontal ligament, its mechanical behavior is very dependent on the type of loading (compressive vs. tensile loading; static vs. cyclic loading; uniaxial vs. multiaxial) and the location around the root (cervical, middle, or apical). These different aspects of the periodontal ligament make it difficult to develop a functional biomaterial to treat periodontal attachment due to periodontal diseases. This review aims to describe the structural and biomechanical properties of the periodontal ligament. Particular importance is placed in the close interrelationship that exists between structure and biomechanics: the periodontal ligament structural organization is specific to its biomechanical environment, and its biomechanical properties are specific to its structural arrangement. This balance between structure and biomechanics can be explained by a mechanosensitive periodontal cellular activity. These specifications have to be considered in the further tissue engineering strategies for the development of an efficient biomaterial for periodontal tissues regeneration.