论文标题
两个身体问题：跨变质鸿沟的本体感受和运动控制
The two body problem: proprioception and motor control across the metamorphic divide
论文作者
论文摘要
就像火箭被驱动到太空一样，Evolution已经通过多个阶段进行了设计的苍蝇，以成年为成年。苍蝇发展并部署了两个不同的物体，与变形的变革过程有关。苍蝇幼虫是一种柔软的液压管，可以爬行以找到食物并避免捕食者。成年苍蝇具有僵硬的外骨骼，带有能够长距离导航和丰富社交互动的清晰四肢。由于幼虫和成人形式的结构是如此独特，因此它们需要不同的策略来传感和移动身体。因此，变质分歧为神经回路进行比较分析提供了机会。在这里，我们回顾了了解幼体和成年果蝇的本体感受和运动控制的神经机制的最新进展。我们强调了共同点，这些共同点指出了感觉运动控制的一般原则以及可能反映了生物力学施加的独特约束的差异。最后，我们讨论了对苍蝇和其他动物物种中神经回路结构进行比较分析的新兴机会。
Like a rocket being propelled into space, evolution has engineered flies to launch into adulthood via multiple stages. Flies develop and deploy two distinct bodies, linked by the transformative process of metamorphosis. The fly larva is a soft hydraulic tube that can crawl to find food and avoid predators. The adult fly has a stiff exoskeleton with articulated limbs capable of long-distance navigation and rich social interactions. Because the larval and adult forms are so distinct in structure, they require distinct strategies for sensing and moving the body. The metamorphic divide thus presents an opportunity for comparative analysis of neural circuits. Here, we review recent progress toward understanding the neural mechanisms of proprioception and motor control in larval and adult Drosophila. We highlight commonalities that point toward general principles of sensorimotor control and differences that may reflect unique constraints imposed by biomechanics. Finally, we discuss emerging opportunities for comparative analysis of neural circuit architecture in the fly and other animal species.
