论文标题
在表面上滑动：带有固定和移动配体的颗粒
Sliding across a surface: particles with fixed and mobile ligands
论文作者
论文摘要
界面功能化颗粒的迁移率的定量模型对于理解生物学和纳米技术中的重要系统是关键的。在这项工作中，我们研究了通过配体受体桥锚定在功能化表面上的颗粒的新兴动力学。我们考虑具有可逆桥的系统，其中配体受体对与有限反应速率结合/解开。对于给定的一组桥梁，由于桥梁的扩展性是有限的，因此粒子可以探索一小部分表面。我们显示时间尺度如何比桥梁的寿命更长，粒子的平均位置从其初始值扩散。我们将发现提炼成两个分析方程，以使带有移动和固定配体的颗粒的滑动扩散常数。我们使用反应扩散模拟对我们的理论预测进行定量验证。我们的结果以及最近的文献将允许从实验轨迹中推断出复杂的生物系统中的微观参数。
A quantitative model of the mobility of functionalized particles at the interface is pivotal to understanding important systems in biology and nanotechnology. In this work, we investigate the emerging dynamics of particles anchored through ligand-receptor bridges to functionalized surfaces. We consider systems with reversible bridges in which ligand-receptor pairs bind/unbind with finite reaction rates. For a given set of bridges, the particle can explore a tiny fraction of the surface as the extensivity of the bridges is finite. We show how at time scales longer than the bridges' lifetime, the averaged position of the particle diffuses away from its initial value. We distill our findings into two analytic equations for the sliding diffusion constant of particles carrying mobile and fixed ligands. We quantitatively validate our theoretical predictions using reaction-diffusion simulations. Our results, along with recent literature, will allow inferring the microscopic parameters at play in complex biological systems from experimental trajectories.
