论文标题

与疟疾和G6PD缺乏症的局部分位数疾病映射

Joint Quantile Disease Mapping with Application to Malaria and G6PD Deficiency

论文作者

Alahmadi, Hanan, Rue, Håvard, van Niekerk, Janet

论文摘要

与平均回归方法相比,基于分位数回归方法的统计分析对离群值的统计分析更全面,灵活且对异常值较差。当相关疾病之间的联系时,关节疾病映射对于测量它们之间的方向相关性很有用。大多数研究通过多个相关的平均回归研究了这种联系。在本文中,我们提出了一个可以考虑可以考虑不同分位水平的多种疾病的联合分位回归框架。我们的动机是由疟疾和基因缺乏型G6PD之间的理论联系的动机。无法通过平均回归进行研究,因此需要在疾病映射框架中柔性关节分位回归。我们的关节分位数疾病映射模型可用于随机花纹的协变量的线性和非线性效应,因为我们将其定义为潜在的高斯模型。我们使用R软件包INLA中嵌入的INLA框架对此模型进行贝叶斯推断。最后,我们通过使用不同级别的链接分位数分析21个非洲国家的疟疾和G6PD缺乏率,从而说明了模型的适用性。

Statistical analysis based on quantile regression methods is more comprehensive, flexible, and less sensitive to outliers when compared to mean regression methods. When the link between different diseases are of interest, joint disease mapping is useful for measuring directional correlation between them. Most studies study this link through multiple correlated mean regressions. In this paper we propose a joint quantile regression framework for multiple diseases where different quantile levels can be considered. We are motivated by the theorized link between the presence of Malaria and the gene deficiency G6PD, where medical scientist have anecdotally discovered a possible link between high levels of G6PD and lower than expected levels of Malaria initially pointing towards the occurrence of G6PD inhibiting the occurrence of Malaria. This link cannot be investigated with mean regressions and thus the need for flexible joint quantile regression in a disease mapping framework. Our joint quantile disease mapping model can be used for linear and non-linear effects of covariates by stochastic splines, since we define it as a latent Gaussian model. We perform Bayesian inference of this model using the INLA framework embedded in the R software package INLA. Finally, we illustrate the applicability of model by analyzing the malaria and G6PD deficiency incidences in 21 African countries using linked quantiles of different levels.

扫码加入交流群

加入微信交流群

微信交流群二维码

扫码加入学术交流群,获取更多资源