论文标题
使用对齐的磁性骨水泥在临床安全限制以下的兔子抑制兔子的骨肿瘤
Bone tumor suppression in rabbits by hyperthermia below the clinical safety limit using aligned magnetic bone cement
论文作者
论文摘要
在临床安全的场参数下，在生理环境中证明了纳米颗粒的高效交替电流（AC）磁场加热，这仍然是一个巨大的挑战，阻碍了磁性高温的临床应用。在这项工作中，我们报告了AC场参数的临床安全限制下磁性骨水泥的高损失能力，并结合了浓度较低的DC场一致的软磁ZN0.3FE2.7O4纳米颗粒。在430 kHz的4 ka/m的交流场下，与0.2 wt％纳米颗粒的排列骨水泥在180 s的温度升高30 c。这相当于特定的损失功率值为327 w/gmetal，与随机取向样品相比，固有损耗功率为47 NHM^2/kg，相比之增加了50倍。高性能的磁性骨水泥可以证明有效的高温抑制肿瘤生长在新西兰白兔子的骨髓腔中，由于血液循环而受到快速冷却，并显着提高了存活率。
Demonstrating highly efficient alternating current (AC) magnetic field heating of nanoparticles in physiological environments under clinically safe field parameters has remained a great challenge, hindering clinical applications of magnetic hyperthermia. In this work, we report exceptionally high loss power of magnetic bone cement under clinical safety limit of AC field parameters, incorporating DC field-aligned soft magnetic Zn0.3Fe2.7O4 nanoparticles with low concentration. Under an AC field of 4 kA/m at 430 kHz, the aligned bone cement with 0.2 wt% nanoparticles achieved a temperature increase of 30 C in 180 s. This amounts to a specific loss power value of 327 W/gmetal and an intrinsic loss power of 47 nHm^2/kg, which is enhanced by 50-fold compared to randomly oriented samples. The high-performance magnetic bone cement allows for the demonstration of effective hyperthermia suppression of tumor growth in the bone marrow cavity of New Zealand White Rabbits subjecting to rapid cooling due to blood circulation, and significant enhancement of survival rate.
