论文标题
从小动物的胸部X射线射线的区域肺气体积的准确度量
Accurate measures of regional lung air volumes from chest X-rays of small animals
论文作者
论文摘要
我们提出了一种可靠的技术，用于计算肺内从通风过程中捕获的X射线X光片序列中的区域体积变化，而无需使用计算机断层扫描（CT）。该技术基于空气置换衰减的肺组织时，每个肺部区域发生的X射线强度的变化。根据X射线强度变化计算得出的肺气体积显示与真实体积相关性（$ r^2 $ = 0.98），该相关性通过高分辨率CT测量。这种相关性使我们能够将投影强度数据准确地转换为肺气体积的相对变化。我们已经应用了此技术来测量从机械通气，最近灭绝的新生兔子的X射线图像序列的区域肺体积的变化，而无需使用CT。该方法适用于生物医学研究，并显示了临床应用的潜力。
We present a robust technique for calculating regional volume changes within the lung from X-ray radiograph sequences captured during ventilation, without the use of computed tomography (CT). This technique is based on the change in transmitted X-ray intensity that occurs for each lung region as air displaces the attenuating lung tissue. Lung air volumes calculated from X-ray intensity changes showed a strong correlation ($R^2$=0.98) against the true volumes, measured from high-resolution CT. This correlation enables us to accurately convert projected intensity data into relative changes in lung air volume. We have applied this technique to measure changes in regional lung volumes from X-ray image sequences of mechanically ventilated, recently-deceased newborn rabbits, without the use of CT. This method is suitable for biomedical research studies and shows potential for clinical application.
