论文标题
统计和仿真模型（PRISM）的可编程接口：临床和医疗保健决策模型的更大可访问性
Programmable Interface for Statistical & Simulation Models (PRISM): Towards Greater Accessibility of Clinical and Healthcare Decision Models
论文作者
论文摘要
背景：越来越多的医疗保健决策依赖于计算机模型，无论是在护理点还是在决策水平上的临床预测模型或决策分析模型。鉴于模型在这两种情况下都扮演着重要的榜样，因此对其结构和实施进行了严格的审查。在不面对障碍的情况下询问输入/输出关联的能力可以改善质量保证机制，同时满足隐私/机密性问题并促进模型将模型整合到决策中。本文报告了用于统计和仿真模型（PRISM）的可编程接口的开发，这是一个基于云的模型可访问性平台。方法：PRISM强调两个主要原则：1）模型开发人员侧面的最小规格，以使模型适合云托管，2）使客户访问完全独立于模型的资源要求和软件依赖性。服务器体系结构集成了一个恢复的应用程序编程接口（API）基础架构，用于数据传输的JSON，用于访问管理的路由层，用于管理计算机资源和包装依赖项的容器技术以及同步或异步模型调用的能力。结果：我们讨论了构建结构，最小的API标准，该标准启用了通用语言以访问此类模型，基础服务器基础架构以及用于数据传输的标准。通过PEER Models网络http://peermodelsnetwork.com，可以作为服务的实例作为服务。通过一系列案例研究，我们证明了如何以标准化方式进行审问模型，无论任何模型的细节如何。结论：我们已经开发了一个公共访问的平台和简约的标准，可促进临床和政策模型的模型可访问性。
Background: Increasingly, decision-making in healthcare relies on computer models, be it clinical prediction models at point of care or decision-analytic models at the policymaking level. Given the important role models play in both contexts, their structure and implementation be rigorously scrutinized. The ability to interrogate input/output associations without facing barriers can improve quality assurance mechanisms while satisfying privacy/confidentiality concerns and facilitating the integration of models into decision-making. This paper reports on the development of Programmable Interface for Statistical & Simulation Models (PRISM), a cloud-based platform for model accessibility. Methods: PRISM emphasizes two main principles: 1) minimal specifications on the side of model developer to make the model fit for cloud hosting, and 2) making client access completely independent of the resource requirement and software dependencies of the model. The server architecture integrates a RESTful Application Programming Interface (API) infrastructure, JSON for data transfer, a routing layer for access management, container technology for management of computer resources and package dependencies, and the capacity for synchronous or asynchronous model calls. Results: We discuss the architecture, the minimal API standards that enable a universal language for access to such models, the underlying server infrastructure, and the standards used for data transfer. An instance of PRISM is available as a service via the Peer Models Network http://peermodelsnetwork.com. Through a series of case studies, we demonstrate how interrogating models becomes possible in standardized fashion, in a way that is irrespective of the specifics of any model. Conclusions: We have developed a publicly accessible platform and minimalist standards that facilitate model accessibility for both clinical and policy models.
