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The wellbeing of modern societies is dependent upon the functioning of their infrastructure networks. This paper introduces the 3C concept, an integrative multi-system and multi-stakeholder optimization approach for managing infrastructure interventions (e.g., maintenance, renovation, etc.). The proposed approach takes advantage of the benefits achieved by grouping (i.e., optimizing) intervention activities. Intervention optimization leads to substantial savings on both direct intervention costs (operator) and indirect unavailability costs (society) by reducing the number of system interruptions. The proposed optimization approach is formalized into a structured mathematical model that can account for the interactions between multiple infrastructure networks and the impact on multiple stakeholders (e.g., society and infrastructure operators), and it can accommodate different types of intervention, such as maintenance, removal, and upgrading. The different types of interdependencies, within and across infrastructures, are modeled using a proposed interaction matrix (IM). The IM allows integrating the interventions of different infrastructure networks whose interventions are normally planned independently. Moreover, the introduced 3C concept accounts for central interventions, which are those that must occur at a pre-established time moment, where neither delay nor advance is permitted. To demonstrate the applicability of the proposed approach, an illustrative example of a multi-system and multi-actor intervention planning is introduced. Results show a substantial reduction in the operator and societal costs. In addition, the optimal intervention program obtained in the analysis shows no predictable patterns, which indicates it is a useful managerial decision support tool.