论文标题
步态现象冻结的时间序列分析和建模
Time series analysis and modelling of the freezing of gait phenomenon
论文作者
论文摘要
步态冻结(FOG)是帕金森氏病最令人衰弱的症状之一,与跌倒和失去独立性有关。目前对雾的病理生理机制的理解很少。在本文中,我们将时间序列分析和数学建模相结合,以研究雾现象的动力学。我们关注从踏上冰冻的过渡,并在从振荡性吸引子逃脱到平衡吸引子状态的背景下处理这种现象。我们从实验数据中提取离散时间离散空间马尔可夫链,并将其状态空间划分为通信类,以确定过渡到冻结。这使我们能够开发一种计算方法,以估计冻结的时间以及沿振荡性(踏板)循环的阶段(FE)的振荡(步进)周期。开发的方法是一般的,可以应用于任何时间序列,该时间序列具有不同的动态态度之间的过渡,包括来自雾人的前进行走的时间序列数据。
Freezing of Gait (FOG) is one of the most debilitating symptoms of Parkinson's Disease and is associated with falls and loss of independence. The patho-physiological mechanisms underpinning FOG are currently poorly understood. In this paper we combine time series analysis and mathematical modelling to study the FOG phenomenon's dynamics. We focus on the transition from stepping in place into freezing and treat this phenomenon in the context of an escape from an oscillatory attractor into an equilibrium attractor state. We extract a discrete-time discrete-space Markov chain from experimental data and divide its state space into communicating classes to identify the transition into freezing. This allows us to develop a methodology for computationally estimating the time to freezing as well as the phase along the oscillatory (stepping) cycle of a patient experiencing Freezing Episodes (FE). The developed methodology is general and could be applied to any time series featuring transitions between different dynamic regimes including time series data from forward walking in people with FOG.