论文标题
通过局部灵敏度分析来控制多性性：应用于蜂窝决策网络
Control of Multistability through Local Sensitivity Analysis: Application to Cellular Decision-making Networks
论文作者
论文摘要
从物理学到生物学，对多稳定动力系统的控制具有重要的应用。在这里，我们从局部灵敏度分析的角度攻击了这个问题。我们开发了灵敏度规则，以控制连续时间多稳定动力学的属性，即简单吸引子，即吸引吸引的相对大小和深度。我们的参数控制信号在计算上很便宜，并提供了有关在实验环境中要操纵的敏感参数的违反直觉信息。
Control of multistable dynamical system has important applications, from physics to biology. Here, we attack this problem from the perspective of local sensitivity analysis. We develop sensitivity rules to control properties of continuous-time multistable dynamics with simple attractors, namely, the relative size and depth of their basins of attraction. Our parameter control signal is computationally cheap and provides counter-intuitive information about the sensitive parameters to be manipulated in an experimental setting.
