论文标题
通过X射线荧光成像对扫描声显微镜的校准，以分化不稳定和稳定的动脉粥样硬化斑块
Calibration of scanning acoustic microscopy for the differentiation between unstable and stable atherosclerotic plaques by X-ray fluorescence imaging
论文作者
论文摘要
尽管心血管疾病是全球死亡的主要原因，但尚未提供用于鉴定相关的不稳定动脉粥样硬化斑块的无创和廉价诊断工具。扫描声学显微镜为填补患者护理中的这一关键空白提供了很高的潜力。然而，令人信服的验证和校准需要高分辨率的ca浓度的动脉粥样硬化斑块。在这里，我们证明了基于微尺的X射线荧光成像具有微米空间分辨率可以提供这样的金标准。
Although cardiovascular diseases are the leading cause of death globally, non-invasive and inexpensive diagnostic tools for the identification of associated unstable atherosclerotic plaques are not yet available. Scanning acoustic microscopy offers a high potential to fill this critical gap in patient care. However, convincing validation and calibration of this technique requires high resolution maps of Ca concentrations of atherosclerotic plaques. Here, we demonstrate that synchrotron radiation-based X-ray fluorescence imaging with micrometer spatial resolution can provide such a gold standard.
