论文标题
使用MR温度测定法验证激光诱导的热疗模拟模型
Validating a Simulation Model for Laser-Induced Thermotherapy Using MR Thermometry
论文作者
论文摘要
激光诱导的间质热治疗（LITT）用于前体猪肝。人造血管用于研究较大的血管与消融区的冷却作用。使用基于温度，辐射和组织损伤的部分微分方程（PDE）的模型模拟相同的设置。将模拟温度分布与从MR温度计获得的温度数据进行比较。研究表明，温度计数据的质量和分辨率足以验证和改善建模方法。此外，数据可用于识别缺失的模型参数以及激光施加器与成像平面相关的确切位置。
Laser-induced interstitial thermotherapy (LITT) is applied to ex-vivo porcine livers. An artificial blood vessel is used to study the cooling effect of larger blood vessels in proximity to the ablation zone. The same setting is simulated using a model based on partial differential equations (PDEs) for temperature, radiation, and tissue damage. The simulated temperature distributions are compared to temperature data obtained from MR thermometry. The study shows that the quality and resolution of the thermometry data is sufficient to validate and improve modeling approaches. Furthermore, the data can be used to identify missing model parameters as well as the exact placement of the laser applicator in relation to the imaging plane.
