论文标题
金属氧化物纳米颗粒的多功能涂料平台:材料和生物科学的应用
Versatile coating platform for metal oxide nanoparticles: applications to materials and biological science
论文作者
论文摘要
在本功能文章中,我们概述了有关统计共聚物作为金属氧化物纳米颗粒和表面的涂料材料的研究。这些共聚物包含官能团,可与氧化物表面和聚(乙二醇)(PEG)聚合物进行非共价结合,以实现胶体稳定性和隐形性。功能组是磷酸化合物R-H $ _2 $ po $ _3 $的有机衍生物,也称为磷酸,它们因其与金属的强亲和力及其建立多齿结合的能力而被筛选。在此,我们开发了一个基于聚合物的涂料平台,该平台与自组装单层(SAM)和按层(L-B-L)沉积的技术共享特征。这项工作的里程碑是含有多种磷酸基团的基于PEG的共聚物的合成,将多功能性与高颗粒产量的简单方案的实现以及涂层颗粒的胶体稳定性的实验证明。作为演示,涂料研究是在葡萄园(CEO $ _2 $),铁($γ$ -FE $ _2 $ o $ _3 $),铝(Al $ _2 $ o $ _3 $)和钛(Tio $ $ _2 $)的氧化物和不同尺寸和形态的氧化物(Tio $ _2 $)上进行的。我们最终讨论了纳米材料和纳米医学领域的应用。我们评估涂层对可重分散纳米植物的有益作用,体外/体内测定的对比剂和刺激剂反应性颗粒。
In this feature article, we provide an overview of our research on statistical copolymers as a coating material for metal oxide nanoparticles and surfaces. These copolymers contain functional groups enabling non-covalent binding to oxide surfaces and poly(ethylene glycol) (PEG) polymers for colloidal stability and stealthiness. The functional groups are organic derivatives of phosphorous acid compounds R-H$_2$PO$_3$, also known as phosphonic acids that have been screened for their strong affinity to metals and their ability to build multidentate binding. Herein we develop a polymer-based coating platform that shares features with the techniques of self-assembled monolayers (SAM) and Layer-by-Layer (L-b-L) deposition. The milestones of this endeavor are the synthesis of PEG-based copolymers containing multiple phosphonic acid groups, the implementation of simple protocols combining versatility with high particle production yields and the experimental demonstration of the colloidal stability of the coated particles. As a demonstration, coating studies are conducted on cerium (CeO$_2$), iron ($γ$-Fe$_2$O$_3$), aluminum (Al$_2$O$_3$) and titanium (TiO$_2$) oxides of different sizes and morphologies. We finally discuss applications in the domain of nanomaterials and nanomedicine. We evaluate the beneficial effects of coating on redispersible nanopowders, contrast agents for In Vitro/Vivo assays and stimuli-responsive particles.