论文标题

一个模拟优化框架,以改善器官移植系统

A Simulation-Optimization Framework To Improve The Organ Transplantation Offering System

论文作者

Erazo, Ignacio, Goldsman, David, Keskinocak, Pinar, Sokol, Joel

论文摘要

我们提出了一种基于模拟优化的方法,以改善器官移植提供给潜在受体的方式。我们的政策可以应用于所有类型的器官,从本地一级开始实施,相对于多个患者的器官提供,并考虑到正在考虑的器官的质量方面具有灵活性。我们详细描述了我们的仿真优化过程以及它如何使用基本的现实移植数据来告知决策过程。我们使用肝脏和肾脏模型提出结果,我们表明,根据我们的政策建议,使用了更多的器官,并减少了分配器官的所需时间 - 有时会大大减少。

We propose a simulation-optimization-based methodology to improve the way that organ transplant offers are made to potential recipients. Our policy can be applied to all types of organs, is implemented starting at the local level, is flexible with respect to simultaneous offers of an organ to multiple patients, and takes into account the quality of the organs under consideration. We describe in detail our simulation-optimization procedure and how it uses underlying real-world transplant data to inform the decision-making process. We present results using our liver and kidney models, where we show that, under our policy recommendations, more organs are utilized and the required times to allocate the organs are reduced -- sometimes dramatically.

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