论文标题
X射线相对比层析成像，以评估多发性硬化症动物模型中多器官损伤的顺序演变
X-ray Phase Contrast Tomography to assess the sequential evolution of multi-organ damage in an animal model of multiple sclerosis
论文作者
论文摘要
我们在多器官的方法中使用X射线相位对比度层析成像（XPCT）来识别EAE动物模型中多发性硬化症（MS）的早期成像标记。作为大多数神经退行性疾病，MS的特征是在不同的器官和系统中逐渐积累了生物缺陷。需要对不同疾病的网络以及从单个细胞到整个器官的多尺度成像的同时成像，以提供完整的可靠信息。 XPCT提供了在多尺度方法中研究大脑，肠道和眼睛水平的结构和细胞改变的前所未有的可能性。在不同时间点处死的天真小鼠和受EAE影响的小鼠之间的比较，以及来自不同器官和不同时间点的数据的相关性，揭示了对疾病可能预测的器官早期变化的鉴定。
We use X-ray phase-contrast tomography (XPCT) in a multi-organ approach to identify early imaging markers predictive of multiple sclerosis (MS) in EAE animal model. As the majority of neurodegenerative diseases, MS is characterized by a progressive accumulation of biological deficits across different organs and systems. A simultaneous imaging of different disease-relevant networks and a multiscale imaging, ranging from the single cell through to the organ as a whole, are required to provide complete reliable information. XPCT offers the unprecedented possibility to investigate structural and cellular alterations at brain, gut, and eye levels in a multiscale approach. The comparison between naive mice and EAE-affected mice sacrificed at different time points and the correlation of the data from different organs and different time points, unveils the identification of early changes in organs possible predictive of the disease.
