论文标题
一种基于观察者的控制器设计的收缩理论方法，用于患有患者内变异性的1型糖尿病中的葡萄糖调节
A contraction theory approach to observer-based controller design for glucose regulation in type 1 diabetes with intra-patient variability
论文作者
论文摘要
尽管人造胰腺在1型糖尿病患者的70-180 mg/dL的安全范围内有效调节血糖，但患者内的高可变性以及外源性饮食障碍却带来了严重的挑战。因此，现有的控制算法需要其他安全算法和进率的动作。此外，人造胰腺中胰岛素传感器的不可用使这项任务更加困难。在目前的工作中，在收缩分析框架中，考虑了基于观察者的控制器设计的1型糖尿病（T1D）的皮下模型。已经研究了三名虚拟T1D患者的各种现实的多个膜情景，+30％和-30％的参数变异性。发现三名T1D患者所花费的平均时间分别为77％，73％和76％。在没有采取任何进餐率的情况下，在高血糖（> 180 mg/dl）上花费的时间显着减少。
While the Artificial Pancreas is effective in regulating the blood glucose in the safe range of 70-180 mg/dl in type 1 diabetic patients, the high intra-patient variability, as well as exogenous meal disturbances, poses a serious challenge. The existing control algorithms thus require additional safety algorithms and feed-forward actions. Moreover, the unavailability of insulin sensors in Artificial Pancreas makes this task more difficult. In the present work, a subcutaneous model of type 1 diabetes (T1D) is considered for observer-based controller design in the framework of contraction analysis. A variety of realistic multiple-meal scenarios for three virtual T1D patients have been investigated with +30 % and -30 % of parametric variability. The average time spent by the three T1D patients is found to be 77 %, 73 % and 76 %, respectively. A significant reduction in the time spent in hyperglycemia (>180 mg/dl) is achieved without any feed-forward action for meal compensation.
