论文标题
由堆叠的多层闪光灯启用的多光谱大区域X射线成像
Multispectral large-area X-ray imaging enabled by stacked multilayer scintillators
论文作者
论文摘要
常规的能量整合黑白X射线成像缺乏X射线光子的光谱信息。尽管X射线光谱(能量)可以通过通常用CDZNTE探测器来区分光子计数技术,但应用于大面积平板X射线成像(FPXI)非常具有挑战性。在此,我们设计了具有不同X射线吸收能力和闪烁光谱的多层堆叠式闪烁器,在这种情况下,可以通过检测每个闪光器的发射光谱来区分X射线能量,因此可以通过彩色或多光谱镜头镜头来检测多光谱X射线成像,从而轻松地获得X射线成像。为了验证这一想法,在经济高效且可扩展的解决方案过程中制造了基于几个新兴金属卤化物的堆叠多层闪烁体,并实验证明了概念验证的多能量FPXI。骨肌肉模型的双能X射线图像清楚地显示了在常规能量整合FPXI中看不见的细节。通过堆叠具有适当厚度的四层专门设计的多层闪光灯,实现了具有四个能量通道的原型FPXI,证明了其对多光谱甚至高光谱X射线成像的扩展。这项研究提供了一种轻松而有效的策略,以实现能源分辨的平板X射线成像。
Conventional energy-integration black-white X-ray imaging lacks spectral information of X-ray photons. Although X-ray spectra (energy) can be distinguished by photon-counting technique typically with CdZnTe detectors, it is very challenging to be applied to large-area flat-panel X-ray imaging (FPXI). Herein, we design multi-layer stacked scintillators of different X-ray absorption capabilities and scintillation spectrums, in this scenario, the X-ray energy can be discriminated by detecting the emission spectra of each scintillator, therefore the multispectral X-ray imaging can be easily obtained by color or multispectral visible-light camera in one single shot of X-ray. To verify this idea, stacked multilayer scintillators based on several emerging metal halides were fabricated in the cost-effective and scalable solution process, and proof-of-concept multi-energy FPXI were experimentally demonstrated. The dual-energy X-ray image of a bone-muscle model clearly showed the details that were invisible in conventional energy-integration FPXI. By stacking four layers of specifically designed multilayer scintillators with appropriate thicknesses, a prototype FPXI with four energy channels was realized, proving its extendibility to multispectral or even hyperspectral X-ray imaging. This study provides a facile and effective strategy to realize energy-resolved flat-panel X-ray imaging.