论文标题
纵向全脑和白质病变细分的开源工具
An Open-Source Tool for Longitudinal Whole-Brain and White Matter Lesion Segmentation
论文作者
论文摘要
在本文中，我们描述并验证了纵向MRI扫描的全脑分割的纵向方法。它建立在现有的全脑分割方法的基础上，该方法可以处理多对比数据并使用白质病变来鲁棒分析图像。此方法在这里扩展了主题特定的潜在变量，这些变量鼓励其分割结果之间的时间一致性，从而使其能够更好地跟踪数十个神经解剖结构和白质病变的微妙形态变化。我们验证了对控制受试者和患有阿尔茨海默氏病和多发性硬化症患者的多个数据集中提出的方法，并将其结果与其原始横截面配方和两种基准测试纵向方法进行比较。结果表明该方法具有更高的测试可靠性，同时对患者组之间的纵向疾病效应差异更为敏感。作为开源神经影像套装FreeSurfer的一部分，公开实施。
In this paper we describe and validate a longitudinal method for whole-brain segmentation of longitudinal MRI scans. It builds upon an existing whole-brain segmentation method that can handle multi-contrast data and robustly analyze images with white matter lesions. This method is here extended with subject-specific latent variables that encourage temporal consistency between its segmentation results, enabling it to better track subtle morphological changes in dozens of neuroanatomical structures and white matter lesions. We validate the proposed method on multiple datasets of control subjects and patients suffering from Alzheimer's disease and multiple sclerosis, and compare its results against those obtained with its original cross-sectional formulation and two benchmark longitudinal methods. The results indicate that the method attains a higher test-retest reliability, while being more sensitive to longitudinal disease effect differences between patient groups. An implementation is publicly available as part of the open-source neuroimaging package FreeSurfer.
