论文标题
在体外硅模型上，仿生聚氨酯涂层纳米颗粒的磁性生物物理表征
Magnetic biophysical characterization of biomimetic polyeth-ylenimine-coated nanoparticles on in vitro silico model
论文作者
论文摘要
了解纳米颗粒（NP）与细胞内炉的生物物理和磁相互作用对于开发有效的纳米载体系统至关重要，用于药物输送应用和靶向纳米物理应用。纳米医学中的最新发现可用于测试重现类似肿瘤模型的体外系统。铁氧化物纳米颗粒可用于诊断，以及良好的药物携带者和磁性高温诱导的治疗性。在本研究中，我们设计了聚乙烯亚胺偶联的超透明铁氧化纳米颗粒（SPIONS），用于在体外硅模型上的靶向递送化学疗法。阿霉素用于治疗包括乳腺癌在内的多种类型的肿瘤。首先通过静电反应将药物包涂的Mul-ti官能化的纳米颗粒逐步组装，逐步组装到多乙醇 - 基因亚胺氧化物纳米颗粒上，并通过静电反应，并允许阿霉素的络合，并使药物涂层的粒子能够抑制近近酸性细胞，而抗卵形的癌细胞则是抗体癌细胞的抗体，这是抗抑郁剂的作用。化学心理治疗剂。在这里，我们证明了一种复杂的策略，可以通过将磁性纳米颗粒与化学治疗性结合通过癌细胞进行精确杀死。
Understanding the biophysical and magnetic interactions of nanoparticles (NPs) with cell mem-branes is critical for developing effective nanocarrier systems for drug delivery applications and targeted nanophysics applications. Recent discoveries in nanomedicine can be used to test an in vitro system that reproduce a similar tumor model. Iron-oxide nanoparticles can be used for diagnosis, as well as a good carrier of drugs and induced therapeutic for magnetic hyperthermia. In the present study, we engineered polyethylenimine-conjugated superparamagnetic iron-oxide nanoparticles (SPIONs) for the targeted delivery of chemotherapeutics on in vitro silico model. Doxorubicin is used to treat numerous types of tumors including breast cancer. The drug-coated mul-ti-functionalized nanoparticles, were assembled stepwise, with doxorubicin adsorbed to polyeth-ylenimine-iron oxide nanoparticles first, by electrostatic reaction and allowed for the complexation of doxorubicin.. The drug-coated particles were able to inhibit growth and proliferation of resistant cancer cells in vitro, indicating that the system has potential to act as an antimetastatic chemo-thermotherapeutic agent. Here, we demonstrated a sophisticated strategy to kill in a precise way only cancer cells by conjugating a magnetic nanoparticle to chemotherapeutic.
