论文标题
丘脑网状核中的间隙连接和同步簇
Gap junctions and synchronization clusters in the Thalamic Reticular Nuclei
论文作者
论文摘要
丘脑网状核（TRN）介导了注意调节，感觉门控和睡眠纺锤体。 TRN中的GABA能间神经元知道会表现出广泛的同步活性模式。 TRN中塑造同步和聚类模式的一项已知贡献来自间隙连接的存在。这些是在特定的连通性体系结构中组织的，这些结构已通过染料和电耦合研究从经验上鉴定出来。我们的研究结合使用计算模型来实现小型网络中的现实连接方案。我们探讨了间隙连接簇对TRN同步模式的大小，强度和分布的潜在影响，以及这些效果如何受其他因素（例如背景抑制水平）调节。
The Thalamic Reticular Nuclei (TRN) mediate processes like attentional modulation, sensory gating and sleep spindles. The GABAergic inter neurons in the TRN are know to exhibit widespread synchronized activity patterns. One known contribution to shaping synchronization and clustering patterns in the TRN is coming from the presence of gap junctions. These are organized in specific connectivity architectures, that have been identified empirically through dye and electrical coupling studies. Our study uses a computational model in conjunction to implement realistic connectivity schemes in a small network. We explored the potential effects of the size, strength and distribution of gap junctional clusters on the synchronization patterns in TRN, and how these effects are modulated by other factors, such as the level of background inhibition.
