论文标题
自然界中发现的条件概率：促进扩散
Conditional Probability as Found in Nature: Facilitated Diffusion
论文作者
论文摘要
转录因子（TF）是调节基因表达的蛋白质。调节机制是通过TF与与其基因相关的特定部分（TF）靶标的结合。特定TF的目标对应于整个DNA中消失的一小部分，与此同时，搜索必须以数十秒钟的速度结束，以实现其生物学目的 - 这使得搜索搜索是一个高利益的问题。促进的扩散是自然界中用于稳健有效的搜索过程中的一种机制。该机制结合了沿着DNA的1D扩散和3D扩散的“偏移”，这有助于TF迅速到达DNA的遥远部分。在本文中，我们提供了有关这种机制的派生，该机制将搜索过程与概率理论（条件概率）中的基本概念联系起来。
Transcription Factors (TFs) are proteins that regulate gene expression. The regulation mechanism is via the binding of a TF to a specific part of the gene associated with it, the TF's target. The target of a specific TF corresponds to a vanishingly small part of the entire DNA, where at the same time the search must end in a matter of tens of seconds at most for its biological purpose to be fulfilled - this makes the search a problem of high interest. Facilitated Diffusion is a mechanism used in nature for a robust and efficient search process. This mechanism combines 1D diffusion along the DNA and "excursions" of diffusion in 3D that help the TF to quickly arrive at distant parts of the DNA. In this paper we provide a derivation concerning this mechanism that links this search process to fundamental concepts in probability theory (conditional probability).
