论文标题
具有自适应卷积神经网络的手术切除的肺肿瘤的自动分割和复发预测
Automated Segmentation and Recurrence Risk Prediction of Surgically Resected Lung Tumors with Adaptive Convolutional Neural Networks
论文作者
论文摘要
肺癌是癌症相关死亡率的主要原因。尽管新技术(例如图像分割)对于改善检测和较早的诊断至关重要,但治疗该疾病仍然存在重大挑战。特别是,尽管治愈性切除次数增加,但许多术后患者仍会出现复发性病变。因此,非常需要预后工具,可以更准确地预测患者复发的风险。 在本文中,我们探讨了卷积神经网络(CNN)在术前计算机断层扫描(CT)图像中存在的肺部肿瘤的分割和复发风险预测。首先,随着医学图像分割的最新进展,剩余的U-NET用于本地化和表征每个结节。然后,确定的肿瘤被传递给第二个CNN,以进行复发风险预测。该系统的最终结果是由随机的森林分类器产生的,该分类器综合了具有临床属性的第二个网络的预测。分割阶段使用LIDC-IDRI数据集,并获得70.3%的骰子得分。复发风险阶段使用了国家癌症研究所的NLST数据集,并获得了73.0%的AUC。我们提出的框架表明,首先,自动结节分割方法可以推广以启用各种多任务系统的管道,其次,深度学习和图像处理具有改善当前预后工具的潜力。据我们所知,这是第一个完全自动化的细分和复发风险预测系统。
Lung cancer is the leading cause of cancer related mortality by a significant margin. While new technologies, such as image segmentation, have been paramount to improved detection and earlier diagnoses, there are still significant challenges in treating the disease. In particular, despite an increased number of curative resections, many postoperative patients still develop recurrent lesions. Consequently, there is a significant need for prognostic tools that can more accurately predict a patient's risk for recurrence. In this paper, we explore the use of convolutional neural networks (CNNs) for the segmentation and recurrence risk prediction of lung tumors that are present in preoperative computed tomography (CT) images. First, expanding upon recent progress in medical image segmentation, a residual U-Net is used to localize and characterize each nodule. Then, the identified tumors are passed to a second CNN for recurrence risk prediction. The system's final results are produced with a random forest classifier that synthesizes the predictions of the second network with clinical attributes. The segmentation stage uses the LIDC-IDRI dataset and achieves a dice score of 70.3%. The recurrence risk stage uses the NLST dataset from the National Cancer institute and achieves an AUC of 73.0%. Our proposed framework demonstrates that first, automated nodule segmentation methods can generalize to enable pipelines for a wide range of multitask systems and second, that deep learning and image processing have the potential to improve current prognostic tools. To the best of our knowledge, it is the first fully automated segmentation and recurrence risk prediction system.