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Single atoms provide an ideal system for utilizing fundamental quantum functions. Their electrons have well-defined energy levels and spin properties. Even more importantly, for a given isotope -- say, $^{12}$C -- all the atoms are identical. This creates a perfect uniformity that is impossible to achieve in macroscopic-size quantum systems. However, herding individual atoms is a very difficult task that requires trapping them with magnetic or optical means and cooling them down to temperatures in the nanokelvin range. On the other hand, the counterpart of single atoms -- the single defects -- may be as good as atom-based quantum systems if not better. These defects, also referred as quantum defects, possess the favorable energy, spin, and uniformity properties of single atoms and remain in their place without the help of precisely tuned lasers. While the number of usable isotopes is set, the combinations of defects and their host material are practically limitless, giving us the flexibility to create precisely designed and controlled quantum systems. Furthermore, as we tame these defects for the quantum world, we bring about transformative opportunities to the classical world in forms such as ultradense electronic devices and precise manufacturing. In this research insight, we introduce some of our recent work on precisely controlled creation and manipulation of individual defects with a scanning tunneling microscope (STM). We also discuss possible pathways for utilizing these capabilities for the development of novel systems for Quantum Information Science (QIS) applications such as quantum information processing and ultrasensitive sensors.